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Can Supplements Help Heal Long COVID? [2025 Guide]

COVID-19 – What You Need to Know and How to Support Your Immune System

Discover the science-backed supplements that may support your immune system and help you recover from lingering COVID-19 symptoms.

TL;DR

COVID-19 may no longer dominate the headlines, but Long COVID continues to impact millions. This article explores what COVID-19 is, how it affects the immune system, and the eight most effective supplement categories for post-COVID recovery.

Science-backed options like Liposomal Glutathione, NMN, Liposomal B-Vitamin Complex, Vitamin D3/K2, and our all-in-one formula V14 are helping people recover energy, reduce inflammation, and restore vitality.

With over 300,000 customers, Youth & Earth supplements have become trusted tools for recovery and longevity.

Table of Contents

What was COVID-19 and why did it matter?

COVID-19 first appeared in December 2019 in Wuhan, China, caused by a previously unknown coronavirus. The virus, later named SARS-CoV-2, spread rapidly due to its high transmissibility and ability to cause severe respiratory illness.

While many recovered with mild symptoms, COVID-19 presented serious risks to the elderly, immunocompromised individuals, and those with underlying health conditions. Over time, it became clear that some people experienced persistent symptoms long after their initial infection cleared—now known as Long COVID.

What does the immune system do?

The immune system is a highly complex network that protects the body from infections, toxins, and abnormal cell changes. It operates through:

  • Innate immunity: the first-line defence against pathogens

  • Adaptive immunity: targeted responses that learn and remember previous infections

A healthy immune system requires a balance of nutrients, rest, and cellular energy. Viral infections can leave it overworked, inflamed, or under-resourced—especially when key co-factors like antioxidants and vitamins are depleted.

What is Long COVID and why does recovery take time?

Long COVID refers to lingering symptoms such as fatigue, brain fog, poor sleep, or shortness of breath that continue weeks or months after the initial infection.

Even if blood tests appear normal, patients may still experience dysfunction at the cellular or mitochondrial level. In these cases, conventional treatment options are limited—so supplemental support targeting immune and energy systems becomes crucial.

What supplements help with Long COVID recovery?

Here are eight supplement categories shown to support recovery from Long COVID by improving mitochondrial energy production, immune balance, and antioxidant defences.

1. Liposomal Glutathione

A master antioxidant depleted during inflammation. Liposomal delivery enhances absorption for detoxification and immune function.
Recommended: Youth & Earth Liposomal Glutathione

2. Liposomal B-Complex Vitamins

Methylated B12, folate, and other active Bs support cellular energy, nervous system recovery, and mental clarity.
Recommended: Youth & Earth Liposomal B-Vitamin Complex

3. Trace Minerals and Magnesium

Zinc, selenium, copper, and magnesium are critical cofactors for immune regulation and enzymatic balance. Check out V14 

4. L-Carnitine

Essential for transporting fatty acids into mitochondria, improving endurance and cellular repair. 

5. Coenzyme Q10 and Alpha-Lipoic Acid

These antioxidant compounds support mitochondrial function, which is often impaired in fatigue-related syndromes.

6. NAD+ Precursors: NMN or NR

NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) help replenish NAD+—a molecule central to energy metabolism and DNA repair.
Recommended: Youth & Earth NMN Sublingual Powder

7. Vitamin D3 with K2

Together, these vitamins help regulate immune signalling and calcium metabolism.
Recommended: Youth & Earth D3/K2

8. Melatonin

Beyond its sleep-regulating effects, melatonin supports mitochondrial health and inflammatory control.

Is there an all-in-one supplement for immune recovery?

Yes. V14 by Youth & Earth combines many of the above supplements into a single, convenient daily drink.

V14 includes:

  • NMNH (an advanced NAD+ precursor)

  • L-Carnitine

  • CoQ10

  • Methylated B Vitamins

  • Trace minerals

  • Antioxidants such as astaxanthin and quercetin

It’s an ideal option for those who want robust immune, mitochondrial, and longevity support without juggling multiple bottles.

How long does it take to recover from Long COVID?

Recovery varies, but many patients using targeted supplementation report improvement within 3–4 months, with full return to health by six months. In one documented case, a 25-year-old patient improved after using Liposomal Glutathione, NMN, B-Complex, and Vitamin D3/K2. Maintenance doses followed.

 

Is liposomal vitamin C still effective post-COVID?

Yes. Vitamin C remains foundational for immune recovery, antioxidant support, and collagen formation. But traditional supplements offer low bioavailability (~14–30%).
Liposomal forms, like Youth & Earth’s Liposomal Vitamin C, bypass absorption limits and deliver up to 1000mg directly to cells.

How do you rebuild your immune system after COVID?

  1. Maintain a healthy lifestyle: sleep, exercise, diet, and stress reduction

  2. Focus on nutrient density: vegetables, lean protein, healthy fats

  3. Support immune and mitochondrial function with supplements like:

  • Liposomal Glutathione

  • NMN or NR

  • Vitamin D3/K2

  • CoQ10 and B-Complex

  • Comprehensive formulas like V14

The immune system is a network—addressing just one part won’t be enough. A holistic strategy is key.

Science Snapshot

Supplement Mechanism Benefit in Long COVID
Glutathione Antioxidant Lowers inflammation, supports detox
NMN / NR NAD+ production Energy metabolism, DNA repair
B-Complex Methylation co-factors Nervous system support, energy
CoQ10 + ALA Mitochondrial enzymes Energy, antioxidant recycling
Vitamin D3/K2 Immune modulation Balances inflammation
Melatonin Circadian & mitochondrial support Sleep, cellular repair

Frequently asked questions (FAQs)

Can supplements replace medical treatment?
No. Supplements are not substitutes for professional medical care but can be powerful adjuncts.

Are Youth & Earth supplements safe to combine?
Yes, our formulations are designed for synergistic use. Always consult your practitioner for personalised advice.

Is V14 enough on its own?
For many, yes. V14 includes NMNH, B-complex, CoQ10, and trace minerals. For more advanced needs, additional targeted support may help.

Do these supplements interfere with vaccines or medications?
Generally no, but always speak with your doctor if you're taking prescription drugs.

Glossary

COVID-19: A viral respiratory disease caused by SARS-CoV-2
Long COVID: A condition where symptoms persist for weeks or months after infection
NAD+: A molecule required for energy production in every cell
Mitochondria: Organelles that generate cellular energy (ATP)
Liposomal: A delivery method that improves absorption of nutrients
NMN/NR: NAD+ precursors used in longevity and recovery support

Author Bio and Medical Review

Edward van Harmelen, Founder of Youth & Earth, is a health optimisation specialist focused on longevity, cellular health, and functional nutrition. This article reflects insights from real customers, scientific literature, and medical advisors.

 

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